THE IMPACT OF PRP RICH PLASMA INJECTIONS VS. CORTICOSTERIODS INJECTIONS IN MANAGING OSTEOARTHRITIS OF KNEE

Abstract

Background: Knee osteoarthritis (OA) is a prevalent degenerative joint disorder associated with chronic pain and functional limitations. Objective: This study aimed to compare the efficacy and safety of PRP versus corticosteroid injections in patients with knee OA. Methods: This prospective, observational study was conducted at the Pakistan Institute of Medical Sciences Islamabad from 10 July 2024 to 20 December 2024. A total of 85 patients diagnosed with primary knee osteoarthritis (based on the American College of Rheumatology clinical criteria) were enrolled in the study. Patients were divided using a computer-generated random number table into two groups. Group A consisted of 43 patients who received a single intra-articular PRP injection, while Group B included 42 patients who were administered a single intra-articular corticosteroid injection (40 mg triamcinolone acetonide).  Results: Both groups showed significant pain and functional improvement at 1 month. However, PRP-treated patients demonstrated sustained improvement at 3 and 6 months, with significantly lower VAS (2.8 ± 0.6 vs. 6.1 ± 0.9) and WOMAC scores (29.5 ± 4.8 vs. 58.9 ± 6.9) compared to the corticosteroid group at 6 months (p < 0.001). ROM improvement was greater in the PRP group (120° ± 5° vs. 109° ± 6° at 6 months). Patient satisfaction (PGA) was also higher in the PRP group (81% vs. 38%). No serious adverse events were reported. Conclusion: PRP injections provide more durable improvements in pain, function, and joint mobility compared to corticosteroids in patients with knee OA. PRP appears to be a safe and effective alternative for long-term management, particularly in mild to moderate cases.