Keywords
ER/PR STATUS AND GRAYSCALE ULTRASOUND
RENAL METASTASIS
BREAST CANCER
How to Cite
Abstract
Objectives: To analyzing serum levels of urea /creatinine and gray scale ultrasound in patients of breast cancer to check renal metastasis. A correlation of tumor markers ER/PR with TNM staging was also done.
Study Design: Cross-sectional study
Place and Duration of Study: This study was conducted at the JINNAH POST GRADUATE MEDICAL CENTER; KARACHI; PAKISTAN from August 2017 to November 2018.
Methods: Study design was approved by Board of Advance Studies, University of Karachi and ethical committee of Jinnah Post Graduate Medical Centre. Tumor markers ER/PR status was checked by stained tissue histology under microscope received embedded in formalin. Serum urea and creatinine were estimated via using Selectra –E ,XL semi auto biochemical analyzer. Gross kidney metastasis evaluated by ultrasound which is routinely done of each patient.
RESULT: Creatinine gives significant negative correlation with T (p<0.01), Urea gives significant negative correlation with T (p=0.01), significant negative correlation with N (p<0.01) and significant negative correlation with M (p=0.01), ER gives significant positive correlation with T (p<0.01), significant negative correlation with M (p=0.02), whereas PR gives 20.6% negative correlation with N (p<0.01). The results using multivariate analysis, increase in T will give 0.05 unit decrease in Creatinine (p=0.02), no significant effect of T, N and M was observed on Urea, patients with higher T, N, and M values were found significantly more likely for positive ER and patients with higher N were significantly less likely to be found with positive PR (p<0.01).
CONCLUSIONS: As result of study showed no significant effect of T,N and M was observed on serum Urea, creatinine values. Positive ER cases showed higher N values although were significantly less likely to be found with positive PR). Ultrasound findings were negative for metastasis almost in all patients.