Keywords
Magnesium sulfate
Hemodynamics
How to Cite
Abstract
Objective: To evaluate the effect of Magnesium sulphate in attenuating hemodynamic responses to pneumoperitoneum during laparoscopic cholecystectomy (LC).
Methods: For this randomized controlled trial (RCT), we enrolled patients aged 20-60 years who were scheduled for LC. The study took place in the Department of Anesthesiology at Liaquat National Hospital and Medical College in Karachi from March 2025 to April 2025. The intervention group (Group M), received an intravenous injection of the MgSO4 30 mg/Kg over a period of five minutes prior to the establishment of pneumoperitoneum. In contrast, the Control group (Group C) was treated with an equal volume of 0.9% normal saline (NS). Hemodynamics i.e. SBP, DBP, MAP and HR were noted at different time intervals.
Results: The average age of participants in Group C was 48.67 (±15.03) years, while Group M had an average age of 47.40 (±15.03) years. There was no significant difference in hemodynamic variables at baseline and before creation of pneumoperitoneum. Ten minutes after pneumoperitoneum, significant increases were observed in SBP for Group C at 150.9 ± 23.2 mmHg compared to 127.7 ± 13.7 mmHg for Group M (p < 0.0001). DBP also rose significantly, measuring 92.6 ± 10.0 mmHg for Group C and 72.63 ± 11.0 mmHg for Group M (p < 0.0001). The MAP increased to 112.7 ± 11.5 mmHg for Group C versus 90.1 ± 11.9 mmHg for Group M (p < 0.0001), and HR for Group C was recorded at 91.3 ± 12.0 bpm compared to 75.2 ± 9.0 bpm for Group M (p < 0.0001). However, before extubation again there was no difference in hemodynamic variables DBP that was significantly lower in M group.
Conclusion: Administering intravenous magnesium sulfate (MgSO4) immediately before the induction of pneumoperitoneum significantly helps sustain heart rate and arterial pressure. This intervention promotes hemodynamic stability during the entire period of pneumoperitoneum.