Keywords
Multistring probioticsAcute diarrhea
Pediatric gastroenterology
Diarrhea management
Gut microbiota
How to Cite
Abstract
Objective: To evaluate the effectiveness of Multistring probiotics compared to Multistring probiotics in reducing diarrhea duration, stool frequency, improving stool consistency, and enhancing recovery time in children with severe acute diarrhea.
Methods: A randomized controlled trial (RCT) was conducted among 100 children aged 6 months to 5 years diagnosed with acute diarrhea. Participants were randomly assigned to receive either a Multistring probiotic (Lactobacillus rhamnoses GG) or a Multistring probiotic containing multiple bacterial strains. Clinical outcomes, including diarrhea duration, stool frequency, stool consistency improvement, dehydration recovery, and overall recovery time, were assessed. Statistical analysis was performed using SPSS, with t-tests and chi-square tests applied for comparisons. Logistic regression was conducted to identify predictors of faster recovery.
Results: Children receiving Multistring probiotics showed significantly better outcomes compared to the Multistring group. The Multistring group had a shorter diarrhea duration (4.2 ± 1.1 vs. 5.4 ± 1.2 days, p = 0.002), lower stool frequency (5.2 ± 1.6 vs. 6.5 ± 1.8 times/day, p = 0.004), greater stool consistency improvement (80% vs. 60%, p = 0.01), faster recovery (4.8 ± 1.3 vs. 6.1 ± 1.4 days, p = 0.001), and a higher dehydration recovery rate (88% vs. 75%, p = 0.03). Logistic regression indicated that Multistring probiotics (OR = 2.1, p = 0.002), younger age (OR = 1.5, p = 0.04), normal nutritional status (OR = 1.8, p = 0.01), and mild dehydration (OR = 2.3, p = 0.001) were significant predictors of faster recovery.
Conclusion: Multistring probiotics demonstrated superior efficacy in reducing diarrhea duration, improving stool characteristics, and accelerating recovery in children with severe acute diarrhea. Given these findings, healthcare providers should consider Multistring probiotics as a preferred intervention for pediatric diarrhea management. Future research should explore the long-term impact of Multistring probiotics on gut microbiota and immune function.