THE DIAGNOSTIC ACCURACY OF SONOGRAPHY IN THE ASSESSMENT OF ENDOMETRIAL HYPERPLASIA: A SYSTEMATIC REVIEW

Abstract

Background: Endometrial hyperplasia (EH) is a prevalent condition that arises from the presence of either naturally occurring or externally introduced estrogen, combined with a relative insufficiency of progesterone. It rarely occurs at a younger age of about 35 years. Endometrial cancer ranks as the second most prevalent gynecologic malignancy. This study aims to assess the diagnostic accuracy of sonography in the diagnosis of endometrial hyperplasia by comparing its specificity and predictive values. Methods: This systematic review follows the PRISMA guidelines. A comprehensive literature search was conducted including PubMed, Scopus, Web of Science and Google Scholar etc. Results: A total of 23,300 articles were retrieved from database searches. After removing 1,300 duplicates, 22,000 articles proceeded to screening. During the title and abstract review, 21,500 were excluded for not meeting inclusion criteria, leaving 500 for full-text assessment. After a detailed review, 490 were excluded due to issues like insufficient data, poor methodology, or lack of relevance. Ultimately, 10 high-quality studies were selected for the systematic review. Conclusion: This systematic review demonstrates the accuracy of sonography in diagnosing endometrial hyperplasia. Findings indicate that transvaginal ultrasound (TVUS), especially with Doppler studies, is a non-invasive and effective method for detecting endometrial thickening and abnormalities suggestive of hyperplasia.