ASSOCIATION BETWEEN SERUM URIC ACID AND BLOOD PRESSURE IN DIFFERENT AGE GROUPS

Abstract

Objective: To determine frequency of hyperuricemia and its association with blood pressure between different age groups among the patients attending outpatient clinics for general health check-ups in a tertiary care hospital. Study design: Quasi-experimental (case-control) Place and duration of study: Department of Internal Medicine, Fazaia Ruth Pfau Medical College, PAF Faisal Base, Karachi from 18-11-2024 to 20 -02-2025 Methodology: After addressing ethical concerns, this case-control quasi-experimental study was performed to find the frequency of hyperuricemia in patients who were un-diagnosed with hypertension before and find out age associated correlation. A sample of 200 patients was recruited consisting of 100 hypertensive patients and 100 age-matched (non-hypertensive) controls. The principal outcome variable was the frequency of hyperuricemia in patients with high blood pressure compared to controls with normal blood pressure. The secondary outcome was the comparison of serum uric acid level between the hypertensive patients Results: Sixty-four (64.0%) patients in group-A had hyperuricemia and 36 (36.0) patients had normal uric acid levels. Twenty-one (21.0%) individuals in group-B had elevated serum uric acid levels and 79 (79.0%) had normal serum uric acid levels with p value of <0.001. The mean serum uric acid levels in adolescents were 5.58±1.95 mg/dl and mean serum uric acid levels in geriatric patients was 8.6±1.76 mg/dl with no significant correlation with respect to age Conclusion: We concluded that hyperuricemia has a strong association with high blood pressure but there are no statistically significant age-related differences.