SEVERITY OF PERIPHERAL DIABETIC NEUROPATHY WITH BIOCHEMICAL AND DOPPLER STUDIES

Abstract

Objective: To measure the severity of diabetic neuropathy with biochemical and doppler studies in diabetes-type II patients who never complained of peripheral neuropathy.

Study design: Descriptive study

Place and duration of study: Department of Internal Medicine Fazaia Ruth Pfau Medical College (FRPMC), PAF Base Faisal, Karachi. The duration was six months.

Methodology: After seeking permission from the ethical committee of our hospital, our hospital performed our research with a sample of 135 patients who were subjected to biochemical and doppler studies. The biochemical studies involved glomerular filtration rate and serum cholesterol level and doppler studies involved a novel index pedal acceleration time. The severity of neuropathy (vasculopathy) was based on pedal acceleration time, and we compared it to the glycemic derangements among patients. The demographics were also recorded.

Results:

The primary outcome was the severity of vasculopathy among diabetic patients. Sixty-four (47.4%) patients had mild vasculopathy, 46 (34.1%) patients had moderate vasculopathy and 25 (18.5%) patients had critical vasculopathy. Five patients (20.0%) with mild glycemic derangement had critical vasculopathy, 5 (20.0%) patients with moderate glycemic derangement had critical vasculopathy and 15(75.0%) patients with severe glycemic derangement had critical vasculopathy with p value of 0.001.